The Buffalo Bills (9-2) will host the San Francisco 49ers (5-6) on Sunday, December 1, 2024, at Highmark Stadium in Orchard Park, New York. The Bills lead the AFC East and are coming off a bye week, which has allowed key players to recover from injuries. Quarterback Josh Allen has been instrumental in the team’s success, amassing 3,200 passing yards and 28 touchdowns this season. However, the Bills’ defense will need to address vulnerabilities exposed in recent games, particularly against the run.
The 49ers are dealing with significant injury challenges. Quarterback Brock Purdy is expected to play despite a right shoulder injury, but key players like left tackle Trent Williams and defensive end Nick Bosa have been ruled out. Additionally, linebacker Fred Warner is playing through an ankle fracture. These absences could impact both the offensive line’s protection and the defense’s ability to pressure Josh Allen. The 49ers’ defense has been inconsistent, and facing a high-powered Bills offense in adverse weather conditions—including a forecasted lake-effect snowstorm with over a foot of accumulation and winds up to 30 mph—adds to the challenge. This matchup will test the 49ers’ depth and resilience as they aim to keep their playoff hopes alive.
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